Host-Pathogen Interaction Database

HPIDB Statistics


Last Updated July 29, 2019

Currently HPIDB contains 69,787 unique protein interactions between 66 host and 668 pathogen species. Unique protein interactions are defined by unique values in the following columns: host protein id, pathogen protein id, pmid, interaction type and detection method.

Download the HPIDB (excluding predicted interologs) database in PSI-MITAB(2.5) file format.

Download the HPIDB interolog predictions database in PSI-MITAB(2.5) file format.

You can click on each of the pie chart sections to download the HPIDB records in PSI-MITAB(2.5) file format

1. Distribution of HPIs from different sources.

2. Distribution of the host and pathogen taxon categories in HPIDB.



3. Distribution of abundant host and pathogen species in HPIDB.



4. Most abundant pathogen species in HPIDB.

Pathogen SpeciesHost SpeciesNbr. Interactions
InfluenzaMultiple Hosts11,767
Herpes virusesMultiple Hosts9,152
PapillomavirusesMultiple Hosts8,199
Saccharomyces cerevisiaeMultiple Hosts7,226
Human immunodeficiency virusMultiple Hosts4,896
YersiniaMultiple Hosts4,297
Zika virusMultiple Hosts3,611
Hepatitis C virusMultiple Hosts3,296
BacillusMultiple Hosts3,091
Dengue virusMultiple Hosts1,840
Francisella tularensisMultiple Hosts1,372
Measles virusMultiple Hosts995

5. HPIDB Interolog Predictions

Download HPI interolog predictions

External database citations

  • Aranda, B. et al. (2011) "PSICQUIC and PSISCORE: accessing and scoring molecular interactions."Nat Meth 8 2010; 528-529. doi:10.1038/nmeth.1637. [Nature] [PSICQUIC Registry]
  • Aranda B, Achuthan P, Alam-Faruque Y. et al. (2010) "The IntAct molecular interaction database in 2010."Nucleic Acids Res. 2010; 38:D525-D531. doi: 10.1093/nar/gkp878. [PubMed] [DOI] [http://www.ebi.ac.uk/intact/]
  • Stark C, Breitkreutz BJ, Chatr-Aryamontri A, Boucher L, Oughtred R, Livstone MS, Nixon J, Van Auken K, Wang X, Shi X, Reguly T, Rust JM, Winter A, Dolinski K, Tyers M (2011) "The BioGRID Interaction Database: 2011 update." Nucleic Acids Res. 2011 Jan; 39(Database issue):D698-704. [PubMed] [DOI] [http://www.thebiogrid.org]
  • Ceol A, Chatr Aryamontri A, Licata L, Peluso D, Briganti L, Perfetto L, Castagnoli L, Cesareni G (2010) "MINT, the molecular interaction database: 2009 update." Nucleic Acids Res. 2010 Jan; 38(Database issue):D532-9. [PubMed] [DOI] [http://mint.bio.uniroma2.it/mint]
  • Bader GD, Betel D, Hogue CW (2003) "BIND: the Biomolecular Interaction Network Database." Nucleic Acids Res. 2003; 31:248-250. [PubMed] [http://bond.unleashedinformatics.com]
  • Navratil1 V., de Chassey1 B., Meyniel1 L., Delmotte1 S., Gautier1i C., AndrĂ©3 P.,, Lotteau1 V., and Rabourdin-Combe1 C. (2009) "VirHostNet: a knowledgebase for the management and the analysis of proteome wide virus-host interaction networks." Nucleic Acids Res. 2009 Jan;37(Database issue):D661-8. [PubMed] [DOI] [http://pbildb1.univ-lyon1.fr/virhostnet]
  • The UniProt Consortium (2015) "UniProt: a hub for protein information." Nucleic Acids Res. 43: D204-D212. . [DOI] UniProtKB
  • Xenarios, I; Salwinski, L; Duan, XJ; Higney, P; Kim, SM; Eisenberg, D (2002) "DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions." Nucleic Acids Research 30 (1): 303-5. [DOI] [PMC] [DIP]
  • Goll, J., Rajagopala, S. V., et al. (2008) "MPIDB: The microbial protein interaction database." Bioinformatics Volume 24,Issue 15: 1743-1744. [Bioinformatics] [MPIDB]
  • Brown K.R. and Jurisica I (2005) "Online Predicted Human Interaction Database." Bioinformatics Volume 21,Issue 9: 2076-2082. [Bioinformatics] [I2D]
  • Breuer et al (2013) "InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation." Nucl. Acids Res. 2013; 41 (D1). [Nucl. Acid Res.] [InnateDB]

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