HPIDB3.0
Host-Pathogen Interaction Database
HPIDB Statistics
Last Updated July 29, 2019
Currently HPIDB contains 69,787 unique protein interactions between 66 host and 668 pathogen species. Unique protein interactions are defined by unique values in the following columns: host protein id, pathogen protein id, pmid, interaction type and detection method.
Download the HPIDB (excluding predicted interologs) database in PSI-MITAB(2.5) file format.
Download the HPIDB interolog predictions database in PSI-MITAB(2.5) file format.
You can click on each of the pie chart sections to download the HPIDB records in PSI-MITAB(2.5) file format
1. Distribution of HPIs from different sources.
2. Distribution of the host and pathogen taxon categories in HPIDB.
Host
Pathogen
3. Distribution of abundant host and pathogen species in HPIDB.
Host
Pathogen
4. Most abundant pathogen species in HPIDB.
| Pathogen Species | Host Species | Nbr. Interactions | Influenza | Multiple Hosts | 11,767 |
|---|---|---|
| Herpes viruses | Multiple Hosts | 9,152 |
| Papillomaviruses | Multiple Hosts | 8,199 |
| Saccharomyces cerevisiae | Multiple Hosts | 7,226 |
| Human immunodeficiency virus | Multiple Hosts | 4,896 |
| Yersinia | Multiple Hosts | 4,297 |
| Zika virus | Multiple Hosts | 3,611 |
| Hepatitis C virus | Multiple Hosts | 3,296 |
| Bacillus | Multiple Hosts | 3,091 |
| Dengue virus | Multiple Hosts | 1,840 |
| Francisella tularensis | Multiple Hosts | 1,372 |
| Measles virus | Multiple Hosts | 995 |
5. HPIDB Interolog Predictions
Download HPI interolog predictions
External database citations
- Aranda, B. et al. (2011) "PSICQUIC and PSISCORE: accessing and scoring molecular interactions."Nat Meth 8 2010; 528-529. doi:10.1038/nmeth.1637. [Nature] [PSICQUIC Registry]
- Aranda B, Achuthan P, Alam-Faruque Y. et al. (2010) "The IntAct molecular interaction database in 2010."Nucleic Acids Res. 2010; 38:D525-D531. doi: 10.1093/nar/gkp878. [PubMed] [DOI] [http://www.ebi.ac.uk/intact/]
- Stark C, Breitkreutz BJ, Chatr-Aryamontri A, Boucher L, Oughtred R, Livstone MS, Nixon J, Van Auken K, Wang X, Shi X, Reguly T, Rust JM, Winter A, Dolinski K, Tyers M (2011) "The BioGRID Interaction Database: 2011 update." Nucleic Acids Res. 2011 Jan; 39(Database issue):D698-704. [PubMed] [DOI] [http://www.thebiogrid.org]
- Ceol A, Chatr Aryamontri A, Licata L, Peluso D, Briganti L, Perfetto L, Castagnoli L, Cesareni G (2010) "MINT, the molecular interaction database: 2009 update." Nucleic Acids Res. 2010 Jan; 38(Database issue):D532-9. [PubMed] [DOI] [http://mint.bio.uniroma2.it/mint]
- Bader GD, Betel D, Hogue CW (2003) "BIND: the Biomolecular Interaction Network Database." Nucleic Acids Res. 2003; 31:248-250. [PubMed] [http://bond.unleashedinformatics.com]
- Navratil1 V., de Chassey1 B., Meyniel1 L., Delmotte1 S., Gautier1i C., André3 P.,, Lotteau1 V., and Rabourdin-Combe1 C. (2009) "VirHostNet: a knowledgebase for the management and the analysis of proteome wide virus-host interaction networks." Nucleic Acids Res. 2009 Jan;37(Database issue):D661-8. [PubMed] [DOI] [http://pbildb1.univ-lyon1.fr/virhostnet]
- The UniProt Consortium (2015) "UniProt: a hub for protein information." Nucleic Acids Res. 43: D204-D212. . [DOI] UniProtKB
- Xenarios, I; Salwinski, L; Duan, XJ; Higney, P; Kim, SM; Eisenberg, D (2002) "DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions." Nucleic Acids Research 30 (1): 303-5. [DOI] [PMC] [DIP]
- Goll, J., Rajagopala, S. V., et al. (2008) "MPIDB: The microbial protein interaction database." Bioinformatics Volume 24,Issue 15: 1743-1744. [Bioinformatics] [MPIDB]
- Brown K.R. and Jurisica I (2005) "Online Predicted Human Interaction Database." Bioinformatics Volume 21,Issue 9: 2076-2082. [Bioinformatics] [I2D]
- Breuer et al (2013) "InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation." Nucl. Acids Res. 2013; 41 (D1). [Nucl. Acid Res.] [InnateDB]
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