HPIDB3.0

Host-Pathogen Interaction Database

Predicting Host-Pathogen Interactions


Click here to Download HPIDB predicted interologs

HPIDB biocurators curate host-pathogen interaction (HPI) data from published literature using the International Molecular Exchange Consortium (IMEx) guidelines. However, since there is no experimental evidence available for HPI of many economically important agricultural pathogens, HPIDB also predicts HPI. Currently, we predict HPI using a modified version of the interolog method described by Yu et al., 2004.

Briefly, HPI Interologs are determined by creating a subset of all experimentally validated HPI from IMEx. Host proteins from this subset are then mapped to production animal proteins based upon orthology. Since orthology is not available for pathogen proteins, we use Blast based upon manually reviewed Blast parameters (>= 74 % identity, >= 50% coverage, Eval <= 6e-180 for bacteria, Eval <= 2e-161 for other pathogens) to identify homology between pathogen proteins. Orthologous host proteins and homologous pathogen proteins are then compared to the subset of experimentally validated HPI to identify new interologs.

HostPathogenPredicted Interologs
Bos taurusBovine viral diarrhea virus 117,625
Bos taurusSalmonella enterica subsp. enterica10,236
Bos taurusStaphylococcus aureus6,210
Bos taurusFoot-and-mouth disease virus - type O2,358
Bos taurusSalmonella enterica subsp. enterica serovar Enteritidis1,913
Bos taurusSalmonella enterica subsp. enterica serovar Typhimurium1,784
Bos taurusSalmonella enterica subsp. enterica serovar Heidelberg1,438
Bos taurusSalmonella enterica subsp. enterica serovar Newport1,427
Bos taurusSalmonella enterica subsp. enterica serovar Typhimurium str. LT21,422
Bos taurusSalmonella enterica subsp. enterica serovar Typhimurium str. ST4/741,403
Bos taurusSalmonella enterica subsp. enterica serovar Newport str. SL2541,401
Bos taurusSalmonella enterica subsp. enterica serovar Typhimurium str. 14028S1,394
Bos taurusSalmonella enterica subsp. enterica serovar Typhimurium str. DT1041,392
Bos taurusSalmonella enterica subsp. enterica serovar Typhimurium str. SL13441,391
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo1,381
Bos taurusSalmonella enterica subsp. enterica serovar Kentucky1,375
Bos taurusSalmonella enterica subsp. enterica serovar Agona1,370
Bos taurusSalmonella enterica subsp. enterica serovar Cerro1,366
Bos taurusSalmonella enterica subsp. enterica serovar Oranienburg1,366
Bos taurusSalmonella enterica subsp. enterica serovar Muenchen str. baa15941,360
Bos taurusFoot-and-mouth disease virus - type A1,359
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. CDC 2011K-16741,350
Bos taurusSalmonella enterica subsp. enterica serovar Agona str. SL4831,342
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. S5-4031,031
Bos taurusPasteurella multocida997
Bos taurusBovine viral diarrhea virus 2912
Bos taurusMannheimia haemolytica640
Bos taurusSalmonella enterica subsp. enterica serovar Enteritidis str. P125109450
Bos taurusFoot-and-mouth disease virus - type Asia 1426
Bos taurusSalmonella enterica subsp. enterica serovar Heidelberg str. SL476415
Bos taurusPasteurella multocida subsp. multocida str. Pm70276
Bos taurusStaphylococcus aureus subsp. aureus268
Bos taurusPasteurella multocida subsp. multocida P1062263
Bos taurusPasteurella multocida subsp. multocida OH4807248
Bos taurusMannheimia haemolytica serotype A1/A6 str. PKL10189
Bos taurusStaphylococcus aureus subsp. aureus COL159
Bos taurusStaphylococcus aureus subsp. aureus Mu50157
Bos taurusFoot-and-mouth disease virus - type SAT 2156
Bos taurusStaphylococcus aureus subsp. aureus Z172156
Bos taurusStaphylococcus aureus subsp. aureus str. Newman156
Bos taurusStaphylococcus aureus subsp. aureus MW2154
Bos taurusStaphylococcus aureus subsp. aureus CN1153
Bos taurusStaphylococcus aureus subsp. aureus USA300_TCH959153
Bos taurusStaphylococcus aureus subsp. aureus N315153
Bos taurusStaphylococcus aureus subsp. aureus 71193150
Bos taurusStaphylococcus aureus subsp. aureus MN8149
Bos taurusFoot-and-mouth disease virus - type SAT 1147
Bos taurusStaphylococcus aureus subsp. aureus USA300147
Bos taurusStaphylococcus aureus subsp. aureus NCTC 8325147
Bos taurusStaphylococcus aureus subsp. aureus MRSA252134
Bos taurusStaphylococcus aureus subsp. aureus MSSA476134
Bos taurusStaphylococcus aureus RF122120
Bos taurusStaphylococcus aureus subsp. aureus Mu3117
Bos taurusStaphylococcus aureus subsp. aureus JH9109
Bos taurusStaphylococcus aureus subsp. aureus JH1109
Bos taurusStaphylococcus aureus subsp. aureus USA300_TCH1516101
Bos taurusPasteurella multocida subsp. multocida str. Anand1_buffalo93
Bos taurusFoot-and-mouth disease virus - type SAT 381
Bos taurusBovine alphaherpesvirus 176
Bos taurusFoot-and-mouth disease virus - type C72
Bos taurusClostridium botulinum C/D str. DC561
Bos taurusFoot-and-mouth disease virus46
Bos taurusHistophilus somni 129PT40
Bos taurusSalmonella enterica subsp. enterica serovar Newport str. S0909738
Bos taurusFoot-and-mouth disease virus (strain O1)32
Bos taurusBovine herpesvirus type 1.2 strain K2229
Bos taurusBabesia bovis28
Bos taurusBovine herpesvirus type 1.126
Bos taurusFoot-and-mouth disease virus C125
Bos taurusBabesia bigemina24
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 81038-0123
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. IA_201000828323
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 53195423
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 495297-423
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 41318023
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 495297-323
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. CASC_09SCPH1596523
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. MB101509-007723
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 609458-123
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. MB110209-005523
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. MD_MDA0924950723
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 44660023
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 507440-2023
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. IA_201000828423
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 515920-223
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 31573115623
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 200908331223
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 200908525823
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 19N23
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. IA_201000828523
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. IA_201000828223
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 41487723
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 495297-123
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. IA_201000828723
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 36686723
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. NC_MB110209-005423
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 60946023
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 556150-123
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. IA_200915919923
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 515920-123
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 55615223
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. MB111609-005223
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. 31599657223
Bos taurusSalmonella enterica subsp. enterica serovar Typhimurium str. STM70922
Bos taurusFoot-and-mouth disease virus (strain C3 Indaial)19
Bos taurusFoot-and-mouth disease virus A22/550/Azerbaijan/6519
Bos taurusFoot-and-mouth disease virus (strain C1-Santa Pau)19
Bos taurusFoot-and-mouth disease virus (strain A10-61)19
Bos taurusFoot-and-mouth disease virus (strain A5)19
Bos taurusBovine herpesvirus type 1.2 strain SM02319
Bos taurusBovine herpesvirus type 1.2 strain B58919
Bos taurusBovine herpesvirus type 1.2 strain SP177719
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. MB102109-004719
Bos taurusFoot-and-mouth disease virus (strain A12)19
Bos taurusMycobacterium avium subsp. paratuberculosis18
Bos taurusFoot-and-mouth disease virus (strain A24 Cruzeiro)18
Bos taurusPasteurella multocida subsp. septica17
Bos taurusPasteurella multocida subsp. gallicida17
Bos taurusSalmonella enterica subsp. enterica serovar Montevideo str. OH_200907267517
Bos taurusSalmonella enterica subsp. enterica serovar Typhimurium var. 5-16
Bos taurusMycobacterium avium15
Bos taurusPasteurella multocida subsp. multocida13
Bos taurusBovine herpesvirus type 1.1 (strain P8-2)12
Bos taurusBovine herpesvirus type 1.1 (strain Cooper)12
Bos taurusMycobacterium avium subsp. paratuberculosis K-1011
Bos taurusBovine herpesvirus type 1.1 (strain Jura)8
Bos taurusFoot-and-mouth disease virus O/SKR/20007
Bos taurusFoot-and-mouth disease virus O/swine/19976
Bos taurusFoot-and-mouth disease virus C46
Bos taurusFoot-and-mouth disease virus C36
Bos taurusBabesia divergens6
Bos taurusMycobacterium avium subsp. paratuberculosis 08-82815
Bos taurusFoot-and-mouth disease virus O/UKG/5681/20013
Bos taurusFoot-and-mouth disease virus O/UKG/5470/20013
Bos taurusSalmonella enterica subsp. enterica serovar Muenchen3
Bos taurusFoot-and-mouth disease virus O/HK/20013
Bos taurusFoot-and-mouth disease virus O/UKG/9443/20013
Bos taurusFoot-and-mouth disease virus C53
Bos taurusFoot-and-mouth disease virus O/UKG/4014/20013
Bos taurusFoot-and-mouth disease virus O/UKG/4141/20013
Bos taurusFoot-and-mouth disease virus HKN/20023
Bos taurusFoot-and-mouth disease virus A22/India/17/773
Bos taurusFoot-and-mouth disease virus O/UKG/4998/20013
Bos taurusFoot-and-mouth disease virus O/ES/20013
Bos taurusFoot-and-mouth disease virus C23
Bos taurusFoot-and-mouth disease virus O/UKG/7299/20013
Bos taurusFoot-and-mouth disease virus O/UKG/3952/20013
Bos taurusSalmonella enterica subsp. enterica serovar Typhimurium str. USDA-ARS-USMARC-18993
Bos taurusSalmonella enterica subsp. enterica serovar Typhimurium str. USDA-ARS-USMARC-18103
Bos taurusFoot-and-mouth disease virus O/UKG/7039/20013
Bos taurusSalmonella enterica subsp. enterica serovar Enteritidis str. EC201200053
Bos taurusSalmonella enterica subsp. enterica serovar Enteritidis str. EC200906413
Bos taurusFoot-and-mouth disease virus O/UKG/9161/20013
Bos taurusPasteurella multocida subsp. multocida str. Anand1_cattle2
Bos taurusSalmonella enterica subsp. enterica serovar Typhimurium str. UK-12
Bos taurusBovine viral diarrhea virus 2 C4131
Gallus gallusGallid alphaherpesvirus 24,946
Gallus gallusSalmonella enterica subsp. enterica serovar Enteritidis2,082
Gallus gallusSalmonella enterica subsp. enterica serovar Heidelberg1,586
Gallus gallusSalmonella enterica subsp. enterica serovar Newport1,565
Gallus gallusSalmonella enterica subsp. enterica serovar Newport str. SL2541,524
Gallus gallusSalmonella enterica subsp. enterica serovar Choleraesuis str. SC-B671,499
Gallus gallusSalmonella enterica subsp. enterica serovar Kentucky1,495
Gallus gallusPasteurella multocida1,021
Gallus gallusSalmonella enterica subsp. enterica serovar Enteritidis str. P125109519
Gallus gallusSalmonella enterica subsp. enterica serovar Heidelberg str. SL476477
Gallus gallusClostridium botulinum407
Gallus gallusPasteurella multocida subsp. multocida str. Pm70295
Gallus gallusPasteurella multocida subsp. multocida P1062274
Gallus gallusPasteurella multocida subsp. multocida OH4807267
Gallus gallusClostridium perfringens128
Gallus gallusPasteurella multocida subsp. multocida str. Anand1_buffalo99
Gallus gallusSalmonella enterica subsp. enterica serovar Newport str. S0909745
Gallus gallusMarek's disease herpesvirus type 1 strain MD539
Gallus gallusGallid alphaherpesvirus 122
Gallus gallusPasteurella multocida subsp. gallicida20
Gallus gallusPasteurella multocida subsp. septica20
Gallus gallusGallid herpesvirus 2 strain 81420
Gallus gallusSalmonella enterica subsp. enterica serovar Choleraesuis18
Gallus gallusPasteurella multocida subsp. multocida14
Gallus gallusMycoplasma gallisepticum4
Gallus gallusMycoplasma gallisepticum S64
Gallus gallusMycoplasma gallisepticum str. R(low)4
Gallus gallusMycoplasma gallisepticum WI01_2001.043-13-2P3
Gallus gallusSalmonella enterica subsp. enterica serovar Gallinarum/pullorum3
Gallus gallusPasteurella multocida subsp. multocida str. Anand1_cattle2
Gallus gallusSalmonella enterica subsp. enterica serovar Enteritidis str. EC201200051
Gallus gallusSalmonella enterica subsp. enterica serovar Enteritidis str. EC200906411
Gallus gallusClostridium botulinum C/D str. BKT126951
Ictalurus punctatusEdwardsiella ictaluri 93-14627
Ovis ariesClostridium perfringens B str. ATCC 362615
Sus scrofaPorcine reproductive and respiratory syndrome virus32,434
Sus scrofaPRRSV 16244B88
Sus scrofaPRRSV HB-1(sh)/200288
Sus scrofaPRRSV VR233288
Sus scrofaPRRSV SD 01-0849
Sus scrofaPRRSV HB-2(sh)/200242
Sus scrofaPRRSV HN142
Sus scrofaClostridium sp. K253
TOTAL:208,883

Downloading Interolog Files

HPIDB predicted interologs are available as downloadable MITAB files from HPIDB, and can be included in HPIDB searches.
This tab separated file may be used in Cytoscape for network analysis.
The MITAB_plus file contains 11 additional columns which contains information about the interacting proteins taxon category and sequence.

Interolog Confidence Indicators

Interologs are reviewed to assign confidence indicators, and these are indicated in the Confidence column of the MITAB file (column 15). Please note that the confidence indicator is not meant to be quantitative, but rather should provide a qualitative assessment of support for the prediction. Interologs are assessed based upon biological characteristics of the proteins and assigned the following codes:

I: assigned to all interologs to indicate predicted interactions.

L: indicates that host and pathogen proteins are co-localized (based upon GO CC)

M: indicates HPI containing secreted or membrane bacterial proteins, which are more likely to interact with host proteins (based upon GO CC & BP)

P: indicates HPI containing host proteins involved in replication and host cell defenses (based upon GO BP). Pathogens target these processes to evade the immune response.

D: indicates HPI containing pathogen proteins with domains that commonly interact with host proteins (based upon InterPro).